Sooner Politics.org
  • Front Page
  • Oklahoma News
    • Oklahoma Reports
    • OCPAC
    • Oklahoma Constitution News
    • Citizen of the Year
    • Oklahoma History
    • Today, In History
    • Oklahoma Center Square
    • Faked Out Sports
    • AP Wire
    • NewsBreak Oklahoma
    • Inside the Capitol
    • Lawton Rocks
    • Muskogee Now
    • OSU Sports
  • Podcasts
  • SPTV
    • Fresh Black Coffee, with Eddie Huff
    • AircraftSparky
    • Red River TV
    • Oklahoma TV
    • E PLURIBUS OTAP
    • Tapp's Common Sense
  • Editorial
    • From the Editor
    • Weekend Report
    • 3D Politics
    • Reagan Speaks
  • Sooner Issues
    • Corruption Chronicle
    • Constitutional Grounds
    • State Groups
  • Sooner Analysts
    • OCPA
    • Muskogee Politico
    • Rooke Report
    • SoonerPoll
    • Everett Piper
    • Andrew Spiropoulos
    • Tulsa Devil's Advocate
    • Eddie Huff & Friends
    • 1889 Institute
    • Steve Byas
    • Michael Bates
    • Steve Fair
    • Josh Lewis
    • Tulsa Today
    • OK2A
    • Dr. Jim Meehan
    • AFP Oklahoma
    • Sooner Tea Party
  • Nation
    • Bongino Report
    • Breitbart News
    • Daily wire
    • Steven Crowder
    • InfoWars News
    • Jeff Davis
    • Alex Lains
    • The F1rst
    • Nigel Farage
    • NewsMax
    • America's Voice
    • Ron Paul Institute
    • Bill Gertz
    • Emerald
    • Just the News
    • Trey Gowdy
    • Fox Politics
    • National Commentary
  • Wit & Whimsy
    • Libs of Tiktok
    • It's Still The Law
    • Terrence Williams
    • Witty Cartoons
    • Will Rogers Said
    • Steeple Chasers
    • The Partisan
    • Satire
  • SoonerPolitics.org

Lancet Publishes Good Insights On the Corvid Infection Experience

3/21/2020

Comments

 
  The British medical journal, Lancet; just published a medical research document on the early cases of Covid19. It shows how about 2/3 of those confirmed cases will not need any inpatient services, much less an intensive care designation.
  We apologize for the clinical jargon which is lost on many of us that don't need to use such 'shop talk'. It's our hope that better mass communicators will publish an accurate rewrite of these facts in a manner that the broader public can gain better insights and comprehension from.
​Viral dynamics in mild and severe cases of COVID-19
Yang Liu - Li-Meng Yan - Lagen Wan - Tian-Xin Xiang - Aiping Le - Jia-Ming Liu
Published:March 19, 2020  PDF [306 KB]
DOI: https://doi.org/10.1016/S1473-3099(20)30232-2
​  Coronavirus disease 2019 (COVID-19) is a new pandemic disease. We previously reported that the viral load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) peaks within the first week of disease onset.1,  2 Findings from Feb, 2020, indicated that the clinical spectrum of this disease can be very heterogeneous.3 Here, we report the viral RNA shedding patterns observed in patients with mild and severe COVID-19.
Picture
The Asian medical response has had more time to analyze data than the western nations. Here's one of the first high level papers published in a major medical journal.

Coronavirus disease 2019 (COVID-19) is a new pandemic disease. We previously reported that the viral load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) peaks within the first week of disease onset.
1
,  
2
 Findings from Feb, 2020, indicated that the clinical spectrum of this disease can be very heterogeneous.
3
 Here, we report the viral RNA shedding patterns observed in patients with mild and severe COVID-19.
76 patients admitted to the First Affiliated Hospital of Nanchang University (Nanchang, China) from Jan 21 to Feb 4, 2020, were included in the study. All patients were confirmed to have COVID-19 at the time of admission by RT-PCR. The viral loads of their nasopharyngeal swab samples were estimated with the DCt method (Ctsample – Ctref). Patients who had any of the following features at the time of, or after, admission were classified as severe cases: (1) respiratory distress (≥30 breaths per min); (2) oxygen saturation at rest ≤93%; (3) ratio of partial pressure of arterial oxygen to fractional concentration of oxygen inspired air ≤300 mm Hg; or (4) severe disease complications (eg, respiratory failure, requirement of mechanical ventilation, septic shock, or non-respiratory organ failure). 46 (61%) individuals were classified as mild cases and 30 (39%) were classified as severe cases. The basic demographic data and initial clinical symptoms of these patients are shown in the appendix. Parameters did not differ significantly between the groups, except that patients in the severe group were significantly older than those in the mild group, as expected.
4
 No patient died from the infection. 23 (77%) of 30 severe cases received intensive care unit (ICU) treatment, whereas none of the mild cases required ICU treatment.
We noted that the DCt values of severe cases were significantly lower than those of mild cases at the time of admission (appendix). Nasopharyngeal swabs from both the left and right nasal cavities of the same patient were kept in a sample collection tube containing 3 mL of standard viral transport medium. All samples were collected according to WHO guidelines.
5
 The mean viral load of severe cases was around 60 times higher than that of mild cases, suggesting that higher viral loads might be associated with severe clinical outcomes. We further stratified these data according to the day of disease onset at the time of sampling. The DCt values of severe cases remained significantly lower for the first 12 days after onset than those of corresponding mild cases (figure A). We also studied serial samples from 21 mild and ten severe cases (figure B). Mild cases were found to have an early viral clearance, with 90% of these patients repeatedly testing negative on RT-PCR by day 10 post-onset. By contrast, all severe cases still tested positive at or beyond day 10 post-onset. Overall, our data indicate that, similar to SARS in 2002–03,
6
 patients with severe COVID-19 tend to have a high viral load and a long virus-shedding period. This finding suggests that the viral load of SARS-CoV-2 might be a useful marker for assessing disease severity and prognosis.
Figure thumbnail gr1
FigureViral dynamics in patients with mild and severe COVID-19
Show full caption
  • View Large Image
  • Figure Viewer
  • Download Hi-res image
  • Download (PPT)
We declare no competing interests. This work was supported by the Health and Medical Research Fund (Hong Kong) and Emergency Science and Technology Project for COVID-19 of Jiangxi province ( 202011-2 ).

Supplementary Material

  • Download .pdf (.12 MB)
    Help with pdf files
    Supplementary appendix

References

  1. Pan Y 
    • Zhang D 
    • Yang P 
    • Poon LLM 
    • Wang Q
    Viral load of SARS-CoV-2 in clinical samples.
    Lancet Infect Dis. 2020; (published online Feb 24.)
    https://doi.org/10.1016/S1473-3099(20)30113-4
    View in Article
    • Summary
    • Full Text
    • Full Text PDF
    • Google Scholar
  2. Zou L 
    • Ruan F 
    • Huang M 
    • et al.
    SARS-CoV-2 viral load in upper respiratory specimens of infected patients.
    N Engl J Med. 2020; (published online Jan 30.)
    DOI:10.1056/NEJMc2001737
    View in Article
    • Crossref
    • Google Scholar
  3. Guan WJ 
    • Ni ZY 
    • Hu Y 
    • et al.
    Clinical characteristics of coronavirus disease 2019 in China.
    N Engl J Med. 2020; (published online Feb 28.)
    DOI:10.1056/NEJMoa2002032
    View in Article
    • Crossref
    • Google Scholar
  4. Yang X 
    • Yu Y 
    • Xu J 
    • et al.
    Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
    Lancet Respir Med. 2020; (published online Feb 24.)
    https://doi.org/10.1016/S2213-2600(20)30079-5
    View in Article
    • Scopus (1)
    • Summary
    • Full Text
    • Full Text PDF
    • Google Scholar
  5. WHO
    Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases.
    https://www.who.int/publications-detail/laboratory-testing-for-2019-novel-coronavirus-in-suspected-human-cases-20200117
    Date: 2020
    Date accessed: March 13, 2020
    View in Article
    • Google Scholar
  6. Chu CM 
    • Poon LL 
    • Cheng VC 
    • et al.
    Initial viral load and the outcomes of SARS.
    CMAJ. 2004; 171: 1349-1352
    View in Article
    • Scopus (0)
    • PubMed
    • Crossref
    • Google Scholar

Article Info

Publication History

Published: March 19, 2020

Identification

DOI: https://doi.org/10.1016/S1473-3099(20)30232-2

Copyright

© 2020 Elsevier Ltd. All rights reserved.

ScienceDirect

Access this article on ScienceDirect

Figures

  • Figure thumbnail gr1
    FigureViral dynamics in patients with mild and severe COVID-19

Linked Articles

  • Viral load of SARS-CoV-2 in clinical samples
    • Full-Text
    • PDF
Comments

    Sooner Politics
      Editorial  

    Picture
    David Van Risseghem reports the events and adds some perspective. 


    Search Our Archives.

    Get A Daily News Email

    * indicates required

    Get new posts by email:


    Archives

    August 2022
    July 2022
    June 2022
    May 2022
    April 2022
    March 2022
    February 2022
    January 2022
    December 2021
    November 2021
    October 2021
    September 2021
    August 2021
    July 2021
    June 2021
    May 2021
    April 2021
    March 2021
    February 2021
    January 2021
    December 2020
    November 2020
    October 2020
    September 2020
    August 2020
    July 2020
    June 2020
    May 2020
    April 2020
    March 2020
    February 2020
    January 2020
    December 2019
    November 2019
    October 2019
    September 2019
    August 2019
    July 2019
    June 2019
    May 2019
    April 2019
    March 2019
    February 2019
    January 2019
    December 2018
    November 2018
    October 2018
    September 2018
    August 2018
    July 2018
    June 2018
    May 2018
    April 2018
    March 2018
    February 2018
    January 2018
    December 2017
    November 2017
    October 2017
    September 2017
    August 2017
    July 2017
    June 2017
    May 2017
    April 2017
    March 2017
    February 2017
    January 2017
    December 2016
    November 2016
    October 2016
    September 2016
    August 2016
    July 2016
    June 2016
    May 2016
    April 2016
    August 2015
    January 2015


    Subscribe in a reader
    ​We recently moved our blog. Our archives are still partially stored at our old site. 

    Author

    David Van Risseghem  is the Publisher of SoonerPolitics.org. The resource is committed to informing & mobilizing conservative Oklahomans for civic reform.  This endeavor seeks to utilize the efforts of all cooperative facets of the Conservative movement...

    ​"No politician 'checks off every box" in your list of issues. You have to prioritize and use personal discretion regarding every current and future issue that you can imagine. Then you have to also judge integrity & consistency. A candidate's openness to study the issues & courage to think for themselves. Then you need to review their honesty & work ethic.  I respect any voter's decision, when they've informed themselves and took voting seriously." - David Van Risseghem
​FRONT PAGE •  OKLAHOMA NEWS • EDITORIAL • SOONER ISSUES •​ STATE GROUPS •​ SOONER ANALYSTS •​ LAWMAKER'S JOURNAL •​ NATION •​ NATIONAL COMMENTARY •​ CARTOONS •​ ​
Picture

918 . 928 . 7776

 SoonerPolitics.org is committed to informing & mobilizing conservative Oklahomans for civic reform & restored liberty. We seeks to utilize the efforts of all cooperative facets of the Conservative movement... Content of the diverse columns are solely at the discretion of the dozens of websites who create the content.   David Van Risseghem  is the founder of this platform.
 Sooner Politics News is a platform, not a media site. All our bloggers get their feeds promoted regardless of content. As soon as We suppress or delete even one posting, we become an endorser of whatever We didn't censor..The publisher doesn't (and could not) logically agree with all the content, so we would not expect any rational reader to agree, either. What we do hope, is that readers will think for themselves, and at least be better informed of the issues, events, and values that our citizen journalists work hard to provide for free.. We automate much of the tasks so that our sources' content gets as much exposure as possible. We encourage constructive discussion & debate. The solution is more free speech, not less.​

  • Front Page
  • Oklahoma News
    • Oklahoma Reports
    • OCPAC
    • Oklahoma Constitution News
    • Citizen of the Year
    • Oklahoma History
    • Today, In History
    • Oklahoma Center Square
    • Faked Out Sports
    • AP Wire
    • NewsBreak Oklahoma
    • Inside the Capitol
    • Lawton Rocks
    • Muskogee Now
    • OSU Sports
  • Podcasts
  • SPTV
    • Fresh Black Coffee, with Eddie Huff
    • AircraftSparky
    • Red River TV
    • Oklahoma TV
    • E PLURIBUS OTAP
    • Tapp's Common Sense
  • Editorial
    • From the Editor
    • Weekend Report
    • 3D Politics
    • Reagan Speaks
  • Sooner Issues
    • Corruption Chronicle
    • Constitutional Grounds
    • State Groups
  • Sooner Analysts
    • OCPA
    • Muskogee Politico
    • Rooke Report
    • SoonerPoll
    • Everett Piper
    • Andrew Spiropoulos
    • Tulsa Devil's Advocate
    • Eddie Huff & Friends
    • 1889 Institute
    • Steve Byas
    • Michael Bates
    • Steve Fair
    • Josh Lewis
    • Tulsa Today
    • OK2A
    • Dr. Jim Meehan
    • AFP Oklahoma
    • Sooner Tea Party
  • Nation
    • Bongino Report
    • Breitbart News
    • Daily wire
    • Steven Crowder
    • InfoWars News
    • Jeff Davis
    • Alex Lains
    • The F1rst
    • Nigel Farage
    • NewsMax
    • America's Voice
    • Ron Paul Institute
    • Bill Gertz
    • Emerald
    • Just the News
    • Trey Gowdy
    • Fox Politics
    • National Commentary
  • Wit & Whimsy
    • Libs of Tiktok
    • It's Still The Law
    • Terrence Williams
    • Witty Cartoons
    • Will Rogers Said
    • Steeple Chasers
    • The Partisan
    • Satire
  • SoonerPolitics.org